Areas of Current Research Interest:

• Traditional medicine research
• Natural product research
• Drug Discovery
• Identification of natural bioactive molecules as drugs for treating Inflammation, cancer and Metabolic disorders
• Identification of Novel potential drug candidate and to exploit new bioactivities from already identified molecules
• The area of interest involves the use of proteomics and metabolomics in understanding molecular mechanisms and identifying the role of intracellular molecules in various metabolic disorders.
• Study biomolecular interactions in metabolic disorders and cancer.

Contributions to Teaching:

• At present working as Asst. Professor (on contract basis) in the Dept. of Medical Bio-Chemistry, School of Health Sciences, Kannur University from 2019.
• Worked as Asst. Professor (Guest Faculty) at Central University of Kerala, Kerala from 2018 to 2019.
• Worked as Senior Research Fellow at Mahatma Gandhi University, Kerala from  2012 - 2017
• Worked as Asst. Professor at Sir Syed Institute for Technical Studies, Kerala 2010 to 2012.
• Handled both theory and practical classes for UG and PG in subjects like Medical Biochemistry, Molecular biology and Genetics, Molecular Endocrinology, General /Analytical Biochemistry, Biophysical chemistry and Instrumentation.

Research Experience:

I worked as Junior research fellow and as Senior research fellow in a DST and DBT, Government of India, funded project in Identification of anti-inflammatory bioactive molecules from Ayurvedic medicines. The project involved the identification of the natural molecules and in delineating the mechanism of action in controlling inflammatory pathways. The compounds were isolated by means of chromatographic techniques (HPLC and HPTLC) and were identified by means of high-resolution mass spectrometry (LCMS qTof). The in silico Pharmacokinetic properties of the identified compounds were carried out using ADMET tools. The interaction between the identified compounds and various protein targets and enzymes involved in the inflammatory pathways was determined by in silico molecular docking. In order to identify the mode of action of these compounds in controlling inflammatory pathways, high throughput in vitro enzyme inhibition assays and animal cell culture models were employed. Gene expression studies of various inflammatory genes were done and also the effects of compounds on proinflammatory cytokine pathway were found out.I was actively involved in understanding/ identifying the pathways and bioactive constituents responsible for reducing obesity by an Ayurvedic herbal formulation. The study consists of both in vivo (male Spraque Dawley rats) and in vitro cell culture (3t3l cell lines) experiments. Studies were done on the conversion of preadipocytes to adipocytes, intracellular lipid accumulation by various molecular and fluorescent techniques. The gene expression of various adipokines and other genes was examined. Glucose uptake studies (fluorescently tagged glucose uptake) and proteomics (by LCMS) were also done. The lipid-lowering effect in high-fat diet-fed male SD rats was also carried out. The study also involved the interaction of immune cells with adipose tissues.Besides the above, I have collaborated in determining the anti-inflammatory activity of two plants Elephantopus scaber and Tinospora cordifolia..

Publications/ Journal Research Papers

• Mohind C Mohan, Abhimannue AP, B PK.,. Modulation of Proinflammatory Cytokines and Enzymes by Polyherbal Formulation Guggulutiktaka Ghritam. Journal of Ayurveda and Integrative Medicine, 2019 Jan, Doi: 10.1016/j.jaim.2018.05.007 PMID:30638916
• Mohind C Mohan, Abhimannue AP, B PK.,Identification and Characterization of Berberine in Tinospora cordifolia by Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (LC MS/MS Q-tof) and Evaluation of its anti- Inflammatory Potential. Pharmacognosy Journal.; 20179(3): 350-355. Doi:10.5530/pj.2017.3.59
• Jacob, J., Babu, B.M., Mohind C Mohan, Abhimannue, A.P., Kumar, P.B., 2017. Inhibition of pro-inflammatory pathways by bioactive fraction of Tinospora cordifolia. Inflammopharmacol., 2018 Apr;26(2):531-538,  Doi: 10.1007/s10787-017-0319-2.PMID: 28197798 IF 3.838
• Abhimannue, A.P., Mohind C Mohan, Kumar, B.P.,. Inhibition of Tumor Necrosis Factor-α and Interleukin-1β Production in Lipopolysaccharide-Stimulated Monocytes by Methanolic Extract of Elephantopus scaber Linn and Identification of Bioactive Components. Appl. Biochem. Biotechnol. 2016 Jun;179(3):427-43 Doi:10.1007/s12010-016-2004-0. PMID:26875087. IF 2.140
• Chinchu JU, Mohind C Mohan, Kumar,B,P, 2019, Evaluation of antiinflammatory potential of Ayurvedic decoction Varanadi Kashayam in THP1 derived macrophages. Ayu (An International Quarterly Journal of Research in Ayurveda) 2019. Doi 10.4103/ayu.AYU_53_18.PMID:31367148
• Abhimannue, A.P., Mohind C Mohan, Kuriakose, E, Kumar, B.P.,. In Silico Screening of Bioactive Molecules from Elephantopus Scaber Linn. For Binding with Cardiac Potassium Ion Channels, Kir 2.1 and Kir 3.1. Journal of practical biochemistry and biophysics; 2016, vol 1 (1), 27-34.
• Kumar, B.P., Abhimannue, A.P., Mohind C Mohan, Jacob, J., Babu, B.M., Inhibition of lipoxygenase by Elephantopus scaber extract and determination of its inhibition pattern. J. Adv. Sci. Res. 2015, 6, 1–5.
• Jacob, J., Kumar, P.B., Abhimannue, A.P., Mohind C Mohan, and Babu, B.M.,. Inhibition of lipoxygenase enzymes by extracts of Tinospora cordifolia: A study of enzyme kinetics. J. Nat. Prod., 2014, 7: 203-209.

Book Chapters

• Mohind.C.Mohan et al., ‘Functional Foods as Ingredients of Drug Preparation’ in K.T.Augusti and P. Faizal (eds),“Role of Dietary Fibers and Nutraceuticals in Preventing Diseases”- Pharma Med Press, Hyderabad. pp.497-502.ISBN :9788188449725